INTRODUCTION
Chronopharmacology: science concerned with the variation in the pharmacological actions of various drugs over biological timings & endogenous
periodicities. Various physiological functions as well as diseases exhibit circadian rhythm; also there are various drugs which follow chronokinetics. Therefore application of chronotherapeutics in such diseases can maximise the efficacy & minimize the adverse effects associated with the drugs resulting in improved therapeutic outcome. This study aims on a synchronizing drug treatment to patient circadian rhythms to minimize toxicity (or) adverse effects and maximize efficacy.